Final Project
The Project Proposal is due Friday 14 October.
Use the Project Proposal Submission Form to submit your proposal, which should be a single PDF file containing answers to the seven questions below:
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The names and email ids for all members of your team.
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Title of your project: short description that clearly captures your project idea.
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A short paragraph that describes the goal of your project.
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A project jusfication that explains how your planned project is likely to satisfy at least three of the goals above (fun, relevant, technically interesting, useful).
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State-of-the-art: your understanding of what is already available connected to the goal of your project. This could be other attempts to achieve the same goal (and why you think you can do something better), or work related to similar goals. A good state-of-the-art will include references to specific relevant work. For most types of projects, this would include research papers relevant to your topic.
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A project plan that explains the main tasks needed to successfully complete your project and what you will actually do.
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A management plan list of your team members and their roles and responsibilities. If your team has more than two people, this should also explain how you plan to coordinate and manage your team.
Quiz
Quiz 1 was in class today!
Slides
The slides are here: Class 13: Genotypes and Phenotypes
Some links to materials for the class:
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Charles Darwin. The Variation of Animals and Plants Under Domestication. 1868. (Darwin’s strange (to us today) theory on pangenesis is Chapter XXVII, starting on page 357.)
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Gregor Mendel. Versuche uber Pflanzen-Hybriden. Proceedings of Natural History Society, 1866 English Translation
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R. A. Fisher. Has Mendel’s Work Been Rediscovered?, 15 April 1936. (This isn’t the paper we talked about in class, but is an interesting later one.)
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Matti Pirinen’s GWAS course: Genome-wide Association Studies, University of Helsinki.
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Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen-Yue Tsai, Richard S. Sackler, Chad Haynes, Alice K. Henning, John Paul SanGiovanni, Shrikant M. Mane, Susan T. Mayne, Michael B. Bracken, Frederick L. Ferris, Jurg Ott, Colin Barnstable, Josephine Hoh. Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science, 15 April 2005.
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James J. Lee, et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, August 2018.