Project 3 is due Monday, 21 March.
Final Project idea is due Tuesday, 29 March (4:59pm).
The slides from the 16 March class are here: class15.pdf
Shomu’s Biology: Homologous Recombination
CRISPR Patent Ruling: Decision on Priority 37 C.F.R. § 41.125(a), USPTO 28 February 2022.
Le Cong, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D. Hsu, Xuebing Wu, Wenyan Jiang, Luciano A. Marraffini, Feng Zhang. Multiplex Genome Engineering Using CRISPR/Cas Systems. Science, 3 Jan 2013.
Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris, David R. Liu. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature, April 2016. [PDF] (Base Editing Paper)
Molly OhAinle, Julie A. Kerns, Harmit S. Malik, and Michael Emerman. Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H. Journal of Virology, April 2006.
Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer, Ahmed H. Badran, David I. Bryson and David R. Liu. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature, 23 November 2017.
Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis, Alexander A. Sousa, Luke W. Koblan, Jonathan M. Levy, Peter J. Chen, Christopher Wilson, Gregory A. Newby, Aditya Raguram, and David R. Liu. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature, 21 October 2019. (Prime Editing)