Schedule
(repeated from Class 16)
Quiz 2 will be on Thursday, November 3 and will focus on material from Classes 14 – 18 (mostly on editing genomes, but also including most likely one question on the discussion of Quiz 1 from Class 14.)
Project reports are due Monday, 7 November. This should be a complete project report, which will be graded. You will receive feedback on it, and have an opportunity to revise and improve.
Slides and Links
Slides: Class 18: Crispyr CRISPR
Here’s the video of the conference on human genome editing: https://www.youtube.com/watch?v=pcGALqX_YD8
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Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris, David R. Liu. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature, April 2016. [PDF] (Base Editing Paper)
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Molly OhAinle, Julie A. Kerns, Harmit S. Malik, and Michael Emerman. Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H. Journal of Virology, April 2006.
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Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer, Ahmed H. Badran, David I. Bryson and David R. Liu. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature, 23 November 2017.