Readings
Before Thursday, 8 September:
- Read Chapter 5 of the Bioinformatics Algorithms: How do we compare biological sequences?.
Before next Tuesday, 13 September:
- Read Chapter 19 – 27 of Hubert’s The DNA Book. (Chapter 20 is a bit different, but may be useful to give you ideas for the kinds of things you could do for the Final Project.)
Before next Thursday, 15 September:
- Chapter 26 of Manolis Kellis et al., Computational Biology - Genomes, Networks, and Evolution: Molecular Evolution and Phylogenetics (also available as [PDF]) (if you prefer to watch a video lecture that this chapter is based on, you can watch MIT CompBio Lecture 19 - Phylogenetics).
Slides
The slides are here: Class 5: Analyzing Genomes
Links
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Saul B. Needleman and Christian D. Wunsch. A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins. Journal of Molecular Biology, 1970.
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Since the source of the misguided “6 foot rule” came up in class today, here’s the paper about it: Katherine Randall, E. Thomas Ewing, Linsey Marr, Jose Jimenez, and L. Bourouiba. How Did We Get Here: What Are Droplets and Aerosols and How Far Do They Go? A Historical Perspective on the Transmission of Respiratory Infectious Diseases. April 2021. You’ll also find lots of news articles about this including The 60-Year-Old Scientific Screwup That Helped Covid Kill, Wired Magazine, 13 May 2021. [archive link].