This is an archived file from the Spring 2022 version of the course.
See the current course website for a more recent version.

Class 19: Project Idea Presentations

Schedule The next deliverable for the Final Project is your Project Proposal (see Final Project for details). This is due Friday, 8 April (7:59pm). For teams on the early schedule, this is due on Monday, 4 April (7:59pm) (this is extended from the original deadline, since I forgot to announce this earlier). For the Project Proposal, you should submit a single PDF file using this form with answers to these questions:

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Class 18: Privacy in Genomics

Schedule Final Project idea is due Tuesday, 29 March (4:59pm). You should submit your Final Project Idea using this form, which includes a place to upload a file to use for your presentation. This should be at most two slides that get across the purpose of your project (and include the names of your team). You will present your project idea in class on Wednesday, 30 March. Slides Guest lecture by Anshuman Suri.

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Class 17: Computing with DNA

Schedule Final Project idea is due Tuesday, 29 March (4:59pm). You should submit your Final Project Idea using this form, which includes a place to upload a file to use for your presentation. This should be at most two slides that get across the purpose of your project (and include the names of your team). You will present your project idea in class on Wednesday, 30 March. Slides Slides: class17.pdf

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Class 16: Protein Evolution and Similarity Searching (Guest: William Pearson)

Schedule

Project 3 is due today (Monday, 21 March).

Final Project idea is due Tuesday, 29 March (4:59pm).

Slides

Our guest speaker today was William Pearson (Professor of Biochemistry, and the inventor of FASTA and FASTP). His slides are here: homology.pdf

Class 15: Crispyr CRISPR (aka CRISPR for Beer and Pot)

Schedule Project 3 is due Monday, 21 March. Final Project idea is due Tuesday, 29 March (4:59pm). Slides The slides from the 16 March class are here: class15.pdf Links Shomu’s Biology: Homologous Recombination CRISPR Patent Ruling: Decision on Priority 37 C.F.R. § 41.125(a), USPTO 28 February 2022. Le Cong, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D. Hsu, Xuebing Wu, Wenyan Jiang, Luciano A.

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Class 14: CRISPR for Humans

Schedule Project 3 is due Monday, 21 March. The last day to submit an early Final Project idea is tomorrow (Tuesday, 15 March, 4:59pm). See Final Project for details. Slides The slides from the 14 February class are here: class14.pdf Links Nimrat Chatterjee and Graham C. Walker. Mechanisms of DNA damage, repair and mutagenesis. Enviromental and Molecular Mutagenesis, 9 May 2017. DNA Repair - Providing Chemical Stability for Life - Nobel Prize in Chemistry 2015 to Tomas Lindahl, Paul Modrich and Aziz Sancar.

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Project 3: Multiple Hypothesis Testing and CRISPR

Project 3 is now posted, and is due on Monday, 21 March (as mentioned in class, we are not expecting you to work over spring break, but are posting it now for people who want to get started early). Recall also from Wednesday, that you have the option to start the Final Project early if you have an idea what you want to do and submit an acceptable Project Idea by Tuesday, 15 March (4:59pm) and have it approved.

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Class 13: Final Project Discussions

Class 13 was a discussion of ideas for the Final Project. (There are no other slides or links.)

Final Project

As discussed in Class 4, your final project can be on anything you want that is related to this course. We want your final projects to be interesting and fun to work on, and to produce something of value beyond just satisfying an expectation of this course. We are expecting most students will do one of these types of projects: Systematization Projects: Start with a curious question, learn what is currently understood about it from the research literature, and produce something to explain it to computer scientists.

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Update: CRISPR Patent Ruling

USPTO has made a ruling in the CRISPR patent dispute we talked about yesterday! The ruling is in favor of MIT/Harvard (Broad Institute), determining that they have priority in CRISPR-Cas9 system for editing eukaryotic cells, over the CVC (this is the case name for the Berkeley/University of Vienna assignees of the Doudna/Charpentier patent) patent. (Although this ruling is now in effect, I doubt this well be the end of things, and suspect the CVC lawyers are looking for ways to appeal.

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